C● centred radicals have recently been shown to have striking selectivity in biological systems in sharp contrast to their ROS counterparts. In this lecture we will describe recent observations on the reactivity of fluoroalkyl C● radicals that sit on the cusp in selectivity, with intriguing potential for exploitation in native protein systems. This has allowed not only the ‘zero-size’ labelling of protein systems with sensitive (fluorine-based) probes of function but also the discovery of unexpected reactions that enable powerful yet subtle (including C–C- bond-forming) manipulations. With those small alternations achieved through radical chemistry one can precisely study protein structure and function without impact.

Probing and exploiting the reactivity of C● radicals for selective protein editing

2019 Fall National Meeting

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