The extracellular matrix is a complex assembly of various molecules held together via both covalent and noncovalent interactions. In order to make materials with comparable properties it is proposed that supramolecular materials based on hydrogen bonding units are eminently suitable. Synthetic supramolecular materials can be made that are composed of supramolecular monomers polymerized via similar interactions. This results in dynamic materials. An important challenge in the synthesis and formulation of synthetic extracellular matrices, is besides the balance between dynamics and robustness, the introduction of complexity. This complexity can exist of bioactive molecules that are either supramolecularly or covalently attached to the materials, or might originate from the assembly of the supramolecular monomers into various (hierarchical) structures. Both parameters will heavily influence the function of the materials synthesized when brought into contact with cells and tissues.

Supramolecular polymeric materials as synthetic extracellular matrices: Importance of dynamics and robustness

2019 Fall National Meeting

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