Chitin nanofibers (ChNFs) with mean diameter of ~40 nm and lengths of thousands of nanometers were prepared by TEMPO (2, 2, 6, 6-tetramethylpiperidine-1-oxyl)-mediated oxidation of β-chitin. ChNFs retained the intrinsic bioactivities of chitin, including excellent biocompatibility and high aspect ratios. By using the internal gelation with CaCO<sub>3</sub>-GDL complex and the incorporation of ChNFs as the reinforcing component into alginate matrix, novel and homogeneous ChNFs/calcium alginate sponges (ChNFs/ALG) were prepared. The experimental results showed that ChNFs/ALG sponges exhibited good three-dimensional (3D) structure as well as lamellar and porous morphologies. Animal tests demonstrated that the healing time of wound could be shortened by 2 days and no obvious scar was observed, compared to the commercial gauze. The inflammatory factors produced by the body had no significant change, indicating that the sponges possessed good biocompatibility. In the wound treated by the sponge, the number of inflammatory cells was few, the granulation tissue was more uniform and the collagen deposition was increased, showing that the ChNFs/ALG sponges have good potential in the biomedical material field.<br/> <br/>

Fabrication of chitin nanofiber/calcium alginate sponges and their application as wound healing

2019 Fall National Meeting

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