The structure of the lipd-nucleic acid complexes (lipoplexes) influences the dynamic properties of the lipoplexes, their transfection activity and cytotoxicity. We optimized a protocol for the preparation of pyridinium amphiphile-based lipoplexes through thermal annealing of lipoplexes at medium-high temperature. The impact of this particular thermal treatment towards physicochemical parameters and towards biological properties of the resulted pyridinium amphiphile-based lipoplexes will be presented for several types of lipoplexes, based on different pyridinium amphiphiles.

Impact of thermal annealing on physicochemical properties, serum stability, and transfection efficiency of pyridinium based lipoplexes

2019 Fall National Meeting

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