Coronary artery disease (CAD) is a major leading cause of death in the United States. Suffering from plaque narrowing the blood vessel to lessen blood rate to organs, people with CAD have a higher chance of experiencing a heart attack and stroke. Our research focuses on using a porous structure of iron-containing metal-organic framework (MOF), Fe-MIL family, as a potential coating material for drug eluting stent (DES) to prevent CAD and minimize restenosis and thrombosis. Fe-MILs were composed of iron (III) clusters linked by terephthalate ligands with various crystal structures. Powder X-ray diffraction (XRD) was used to confirm the crystal lattice structure while ultraviolet-visible (UV-Vis) spectroscopy was used to examine and quantify the drug loading amounts in Fe-MILs. Here, we used ibuprofen as a model drug to represent other anti-inflammatory drugs. After comparing drug loading capacities of using various Fe-MILs, we construct a Fe-MIL-88B thin film on a 16-mercaptohexadecanoic acid (MHDA) functionalized gold surface to study the drug loading and releasing kinetics using surface plasmon spectrometer (SPR) and quartz crystal microbalance (QCM). The chemical composition changes after each modification step were monitored by Fourier transform infrared spectroscopy (FTIR) and X-ray photoelectron spectroscopy (XPS). The morphology of the resulting Fe-MIL-88B film before and after loading with the model drug was examined by scanning electron microscopy (SEM). Our study confirmed the use of surface-supportive MOF thin film for drug elution coating purposes.

Studies of surface chemistry of hybrid porous materials for tuning drug delivery efficacy and efficiency

ACS Spring Meeting 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.