Ruthenium complexes bearing both nitrogen and phosphorous based ligands are used in a wide variety of catalytic reactions. These ligands have the ability to tune the electronics of the metal center without changing the steric profile around the metal. Four new ruthenium(II) complexes with the formulas cis-RuCl2[Ph2P(CH2)4PPh2](ampy-L) and trans-RuCl2[Ph2P(CH2)4PPh2](ampy-L) (ampy = 2-(aminomethyl)pyridine; L = Cl or OMe) were synthesized and characterized spectroscopically and electrochemically. Additionally, rates of conversion from the trans- to the cis-isomer were examined to understand the relationship between electronics and isomerization. The complexes were then tested as catalysts for the intramolecular dehydrogenation of amino-alcohols to lactam products.

Synthesis and reactivity of ampy-based ruthenium(II) catalysts for lactam formation

ACS Spring Meeting 2021

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