The development of synthetic anionophores continues to be the focus of a number of groups worldwide due to the potential application of these compounds in the treatment of diseases caused by faulty anion transport (e.g. cystic fibrosis) and in disrupting anion concentration gradients and pH gradients leading to apoptosis and disruption of autophagy.<br/>In this presentation, the development of selective transporters will be described, and how this led to the production of a chloride pumping system capable of creating an anion gradient across a lipid bilayer. The synthesis and complexation properties of new tetraurea macrocycles will also be discussed. A fluorinated version of this macrocycle rivals the natural product prodigiosin in its ability to selectively transport HCl across lipid bilayers but in contrast to the natural product, the macrocycle’s anion transport properties are voltage-gated. The mechanism of this process will be discussed.

Synthetic anionophores for transmembrane transport

ACS Spring Meeting 2021

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