The use of sustainable first-row transition metal catalysts for parahydrogen induced polarization (PHIP) is of significant interest. The use of the cobalt complex (MesCCC)Co-py [MesCCC = bis(2,4,6-trimethylphenyl-enzimidazol-2-ylidene)phenyl), py = pyridine], has been reported for the hydrogenation of olefins, alkynes, and nitriles. Interestingly, the parahydrogenation of ethyl acrylate produced hyperpolarized ethyl propionate in both the 1H and 13C nuclei. Furthermore, the (MesCCC)Co-py catalyst is also capable of the non-hydrogenative hyperpolarization of olefins. A variety of olefinic substrates have been demonstrated for hyperpolarization in the 1H channel and the transfer of polarization to 13C and 19F nuclei will also be presented.

Cobalt-catalyzed parahydrogen induced polarization of olefins

ACS Spring Meeting 2021

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