Transition metal-catalyzed dicarbofunctionalization of alkenes has been proven as a powerful strategy to the rapid generation of molecular complexity by simultaneously forging two vicinal sp3 C–C bonds from abundant building blocks in one single operation; however, selective control, particularly with enantioselective control, of the newly formed stereogenic centers in three-component assembly mode, remains a formidable challenge. Utilizing a nickel-catalyzed radical cascade strategy, we have developed a series of intermolecular, three-component dicarbofunctionalization of unactivated alkenes with excellent selectivity under mild conditions, allowing for facile excess to a wide range of highly functionalized fluoroalkyl-containing molecules from simple starting materials.

Selective, three-component dicarbofunctionalization of unactivated alkenes via nickel catalysis

ACS Spring Meeting 2021

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