Copper(I)-catalyzed synthesis of 1,4-disubstituted-1H-1,2,3-triazoles, ruthenium(II)-catalyzed synthesis of 1,5-disubstituted-1H-1,2,3-triazoles and uncatalyzed, thermal synthesis of 1,4,5-trisubstituted 1H-1,2,3-triazoles, and their NMR characterization data are reported. The NMR data provide definitive structure elucidation in determining the substitution patterns on the triazole moiety scaffolds. The 1D and 2D NMR spectra of the triazole products were elucidated using Mnova software. The 2D methods were essential for the proper annotation of each carbon signal of the 13C NMR spectra. The experiments may be used as an introductory set of experiments for advanced organic laboratory students starting undergraduate organic research. The NMR spectra may be used in conjunction with the synthetic experiments or they may be assigned remotely.

Synthesis and NMR characterization of 1H-1,2,3-triazole derivatives

ACS Spring Meeting 2021

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