POM121C is a protein found in the nuclear pore complex (NPC) located on the nuclear envelope of eukaryotic cells. The NPCs are responsible for the transport of molecules in and out of the cell nucleus and are composed of a variety of nucleoporin proteins. The structure of the NPC and its composite proteins have been the subject of much discussion. While the amino acid sequence of POM121C has been recently discovered, its 3-D structure remains unsolved. By utilizing homology modeling software and bioinformatics tools, we have generated a series of potential 3-D models based on the amino acid sequence of POM121C. Comparative modeling tools were also applied in order to investigate possible structure-function relationships for these models, based on homologous proteins deposited in protein structure databases.

Prediction of the 3-D structure of a nuclear protein

ACS Spring Meeting 2021

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