The Plectranthus genus belongs to the Lamiaceae family and consists of around 300 species distributed from Africa to Asia and Australia. Plectranthus spp. has been reported to be rich in diterpenoids, such as different types of royleanones. One of Plectranthus medicinal plants species is P. hadiensis (Forssk.) Schweinf. ex Sprenger, which contains diverse metabolites such as phenolic and diterpenoid compounds. Furthermore, this plant is widely used in an array of traditional and Ayurveda recipes for the treatment of diverse range of ailments like cancer. Therefore, the aim of this work was to isolate large amounts of the cytotoxic royleanone 7α-acetoxy-6β-hydroxyroyleanone (Figure 1) by fractionation of a P. hadiensis acetonic extract through an ultrasound-assisted extraction method. This royleanone was employed as a starting material for the synthesis self-assembled squalene nanoparticles. The obtained compound was characterized by spectroscopic methods, mainly NMR techniques. Additionally, this royleanone will be studied by cyclic voltammetry in the future. The nanoparticles characterization, the ability to release the drug unit and the preliminary evaluation of their biological activity in different cell lines will be also tested in the future.

Self-assembly nanoparticles of 7α-acetoxy-6β-hydroxyroyleanone isolated from Plectranthus hadiensis

ACS Spring Meeting 2021

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