Cellulose has been used since decades for medical applications but more recently a special interest onto nanoscaled cellulose has been observed. For example, TEMPO-oxidised cellulose nanofibrils (toCNFs), in the form of highly entangled network, such as in membranes or aerogels, have displayed the ability to retain Active Principle Ingredients (API) and give a sustained release over a short period of time. This property, in addition with recent studies assessing the good biocompatibility of the material, has made them promising material for drug release applications. However, some issues need to be addressed for such applications, such as burst release (i.e. rapid initial release of API), increasing the bioavailability of poorly soluble APIs and the limited time of efficient use. The proposition of this work is to use various types of Cyclodextrins (CDs) to design CD-modified toCNF devices suited for drug release. CDs are naturally occurring cage molecules currently used in pharmaceutical and for drug delivery. Sulfadiazine (SD), one of the most commonly used prophylactic agent, is used as a model molecule to characterise the benefit provided by these devices. <br/>We report in this work a study on the complexation process between SD and various types of CDs and the chemical modifications of toCNFs with these CDs (adsorption/grafting) using various methods (ITC, QCM-d, Indirect measurements methods). Main results on final materials show a clear and positive impact of CDs presence over the specific drug release assay but also over the mechanical properties and stability in wet conditions.

Cyclodextrin functionnalized nanocellulose for drug release applications

ACS Spring Meeting 2021

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