Photoprotection is a major issue in public health. Recently, we developed a new sunfilter Phenylene Bis-Diphenyltriazine (TriAsorB) that provides photoprotection in UVB + UVA and visible/infrared light (VIS/IR), especially in the high energy visible (HEV)/Blue light. The aim of this work was to formulate TriAsorB in a new photoprotective system with 3 sunfilters and to explore photoprotection of this innovative SPF50+ sunscreen from UV to VIS/IR light including Blue light. Genoprotection was studied in reconstructed human epidermis (RHE) model exposed to SSR (UV+ VIS light). SSR induced pyrimidine dimers (CPD) and sunscreen topical application prevented DNA lesions. Sun protection was maintained in extreme UV condition. Tissue toxicity and apoptosis were induced after irradiation in human skin model (sunburn cell, CPD and caspase-3). Sunscreen provided an almost complete photoprotection. It was also effective to limit malondialdehyde (MDA) production and superoxide dismutase activity. Immunostaining of 8-hydroxy-2’-deoxyguanosine (8OHdG) confirmed anti-oxidative protection in human skin. Efficiency was then studied in both the VIS and IR. A RHE model was exposed to a Blue LED. HEV light induced tissue oxidation and sunscreen protected the skin against the 8OHdG oxidative lesions. A clinical study showed photoprotection against IR-induced oxidative stress using MDA quantification. IR induced an increase of MDA production and the sunscreen completely protected the forearm against lipid peroxidation. Altogether, an innovative photoprotective system combining TriAsorB with 3 sunfilters provided full-spectrum photoprotection from UV to VIS/IR sunlight. The new sun care product protected the skin against sunlight radiation-induced skin damage including genotoxicity and oxidative stress.

ESDR306 - An innovative sunscreen containing Phenylene Bis-Diphenyltriazine (TriAsorB) provides skin full-spectrum photoprotection against solar radiations

50th Annual Meeting of the European Society for Dermatological Research. VIRTUAL MEETING