The activation of sluggish electrophiles for cross-electrophile coupling reactions vastly widens available building blocks for these transformations. The activation of both C-O bonds and C-N bonds for cross-electrophile coupling reactions has been developed. A nickel-catalyzed cross-electrophile coupling reaction of 1,3-dimesylates as well as a nickel-catalyzed domino reaction of propargyl sulfonamides have been developed. Additionally, to better understand and predict the selectivity of nickel catalysts in coupling reactions, a matrix of cross-electrophile coupling reactions and ligands have been evaluated to construct quantitative structure-activity relationships.

Development of nickel catalyzed cross electrophile coupling reactions

ACS Fall 2021

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