Mesoionics are novel class of insecticides which binds to the orthosteric site of the nicotinic acetylcholine receptor (nAChR) and acts primarily via inhibition of the binding site. Triflumezopyrim (Pyraxalt-TM) is the first commercialized mesoionic insecticide which controls both susceptible and resistant plant hopper and leafhopper populations at low use rates, whereas the other advanced candidate (Dicloromezotiaz) is effective against chewing pest. In this poster, scaffold hopping approach for design and synthesis of novel mesoionic insecticide will be presented.

Mesoioinic insecticide

ACS Fall 2021

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