To determine synergistic anti-obesity effects of prebiotic polyphenol-rich wine grape seed flour (GSF) and paraprobiotic lactic acid bacteria (PLAB), C57BL/6J mice were administered a high-fat and fructose diet (FFD) with 5% microcrystalline cellulose (CON), FFD supplemented with 2.5% GSF, FFD with orally administered PLAB, or FFD with a combination of GSF and orally administered PLAB (GSF+PLAB) for 8 weeks. GSF and PLAB groups both showed significant reductions in FFD-induced body weight gain and adipose tissue<br/>weights as compared with CON. Synergistic effects on the reduction of body body weight gain, visceral adiposity, and plasma triacylglycerol concentrations were observed after combined supplementation with GSF and PLAB. The synergistic action was significantly associated with a decreased adipocyte gene expression in fatty acid synthesis and inflammation metabolism. In conclusion, the combination of prebiotic GSF and paraprobiotic kefir PLAB could be used to prevent obesity and obesity-related diseases, especially for immunocompromised individuals.

Effects of kefir paraprobiotics and flavonoid-rich prebiotics on diet-induced obesity

ACS Fall 2021

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.