All physiological processes tied to cellular replication rely on the chemical integrity of DNA. As such, DNA damage is associated with a range of adverse outcomes such as accelerated aging and cancer, and is the underlying bases of most frontline cancer therapies. However, measuring DNA damage is an analytical challenge due to the low abundance of these events and our inability to specifically amplify DNA damage without losing the chemical information. In this presentation, I will discuss how we apply an interdisciplinary approach, combining mass spectrometry, click chemistry, and biosensing to overcome these challenges to study the occurrence, patterns, and repair of DNA damage. Identifying the patterns of DNA damage, the chemical basis of repair, and how these processes may be modulated, supports our understanding of mechanisms of carcinogenesis and strategies for improving cancer therapeutics.

Chemistry of DNA damage and measuring genomic resilience

ACS Fall 2021

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