All molecules consist of chemical bonds, and much can be learned from mapping the spatiotemporal dynamics of these bonds inside cells, tissue and animals. Since its invention in 2008, stimulated Raman scattering (SRS) microscopy has become a powerful modality for imaging chemical bonds with high sensitivity, resolution, speed and specificity. The past dozen years have witnessed the blossoming of SRS microscopy, where advances in both optical instruments and imaging probes have found broad applications in life sciences. Here we will present the latest innovations in SRS microscopy. In particular, we will highlight three exciting areas in our group: (1) single-molecule vibrational imaging; (2) metabolic imaging in animals; (3) super-multicolor tissue imaging.

Stimulated Raman scattering imaging: The next frontier of light microscopy

ACS Fall 2021

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