The installation of chemical functionality is a fundamental pursuit in organic synthesis. Our research group has recently developed novel methods for the direct incorporation of a sulfonamide unit to a variety of different scaffolds in order to produce libraries of compounds to test for biological activity. In order to expand the set of compounds under investigation, a series of sulfonamide-containing analogs were synthesized using a 4-substituted indole core. Our progress toward the expansion of the set of bioactive indole sulfonamides will be presented.

Synthesis of a library of 4-substituted benzylic N-sulfonyl indole analogs

ACS Spring 2022

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