This work focuses on the synthesis and characterization of moderately water-soluble transition metal complexes. A series of RAPTA “piano-stool” analogs with hydroxylated phosphine ligands and varying arenes were prepared yielding mononuclear and dinuclear complexes. Additionally, platinum and palladium analogs of carboplatin were synthesized utilizing microwave techniques. Their biological activity was investigated using sulforhodamine B assays. Characterization of all compounds was accomplished using multinuclear NMR spectroscopy and single crystal x-ray diffraction.

Synthesis, characterization and biological activity of hydroxylated phosphino transition metal complexes

ACS Spring 2022

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