A study of the reactions of simple meso-epoxides with several lithium amides in the presence of a chiral amine-borane has begun. The effect of variations in solvent, temperature, N-substitution, and order of addition have been investigated using the ratio of allylic to amino alcohols as a measure of mechanistic influence.

Reaction of meso-epoxides with lithium amides in the presence of a chiral amine-borane catalyst

ACS Spring 2022

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