Thermal injury disrupts the immune system homeostasis, leads to the formation of severe hemodynamic disorders, cytokines release, systemic inflammatory response syndrome development, dystrophic processes occurrence, organs and systems dysfunction. One of the leading mechanisms for disorders development is systemic damage to the vascular endothelium. Endothelial dysfunction plays a substantial contributory role in the pathogenesis of burn wound healing and holds potential as a target for therapeutic intervention.
The aim is to study the effect of the combined arginine-carnitine drug (CACD) on some immunological parameters and indicators of endothelial dysfunction in patients with burns.
Methods.
Studies were conducted in the acute period of a burn disease: on 2-3th days, on 7-8th days and on 13-14th days. The use of CACD was carried out from 2-3 days after the burn injury for 5 days, intravenously in a volume of 100 ml 1 time per day.
The contents of such markers of endothelial dysfunction as endothelin-1 (ED-1) and homocysteine in blood and wounds and the contents of pro- and anti-inflammatory cytokines as interleykin-1 (IL-1), IL-6, IL-10 and TNF-α in blood were investigated.
Results are presented in tables 1, 2 and pic.1.
After a course of CACD usage, the tendency to pro-inflammatory cytokines (IL-1, IL-6) levels decrease in the main group is determined, while in the comparison group, there is a tendency to IL-1 and IL-6 levels. On the 13th-14th day after the burn in the main group, a significant increase of anti-inflammatory IL-10 level compared with this indicator in the comparison group. A tendency to decrease in TNF-α levels in the main group is more pronounced than in the comparison group.
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After a course of CACD use there is a decrease in peripheral blood ED-1 levels and a significant decrease in wound ED-1 (p <0.001), significant decrease in homocysteine levels in peripheral blood and wound on a 13-14th day (p<0.001).
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Pic.1
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Conclusions.
As a result of our research we found that combined arginine-carnitine drug usage in the complex treatment in the early period of burn disease and in a burn wound healing promotes reduction of inflammatory reaction manifestations and reduces the degree of endothelial dysfunction.

P.017 The effect of the arginine-carnitine drug usage on immunological parameters and indicators of endothelial dysfunction in patients with burns

Dear friends and colleagues,

We will be pleased to welcome you in Turin (Italy) for the 19th European Burns Association´s Congress in 2022. Italy is honored to hold the meeting of the European Burns Association for the second time, after Verona in 1995. Turin is easily reachable from everywhere in Europe, either travelling by car, train or choosing flight connections. During the meeting, held in the renewed industrial center of the main Italian historical automotive factory (i.e. Lingotto-FIAT), we will meet international burn specialists, focusing on standards of care, progresses in burn treatment, strategies to face disaster situations, with a special attention to education of younger colleagues. However, in your spare time, you might enjoy the sweet days of Italian late summer, simply wandering in the green parks and gardens along the two rivers which cross the city, or you might decide to discover the numerous art galleries, churches, palaces, libraries, walking across elegant squares and large boulevards, passing through centuries of art and history; finally, you may choose to immerse yourself in some of the most exciting museum experiences, such as the Cinema Museum and the Turin’s Egyptian museum.

Looking forward to seeing you all in Turin for the 19th European Association´s Congress in 2022!
Maurizio Stella, Congress President, Turin Burn Centre