Objectives
To determine the feasibility of using a human cadaver to demonstrate enzymatic burn debridement (Nexobrid®) as a training aid for clinical staff.
Methods
An observational proof-of-concept study was carried out. A single, fresh-frozen human cadaver was used. Prior consent had been given. Burns were created by flame and scalding. Unburned control sites also had Nexobrid® applied and were assessed. Nexobrid® enzymatic burn debridement paste was applied to all sites in adherence to the local clinical protocol for treating burned patients. After the removal of Nexobrid®, wounds were assessed to determine if the cadaveric issue appeared similar to what would be expected in living burned patients and whether the technique could be viable for the training of burn care staff.
Results
Nexobrid® had a very similar effect upon burned cadaveric skin to what would have been expected in living burned skin. Both scalded and flame-burned sites of partial-thickness burn depth and full-thickness burn depth were debrided and could be clearly identified. Control sites exhibited no skin loss after Nexobrid® application.
Conclusions
Fresh-frozen human cadaveric tissue is a valid means of training in the enzymatic burn debridement technique. This permits advanced planning of hands-on training courses in the technique. Timetabled cadaveric courses may allow training of greater numbers of students than the more direct but sporadic clinical experience in acute burns units.
In addition, the degree to which the tissues of the cadaveric model mimicked those of living patients and reacted with the Nexobrid® paste was unexpected. This demonstrates that our understanding of the mechanism of action of Nexobrid® at a molecular level is incomplete.

_Objectives_
To determine the feasibility of using a human cadaver to demonstrate enzymatic burn debridement (Nexobrid®) as a training aid for clinical staff.
_Methods_
An observational proof-of-concept study was carried out. A single, fresh-frozen human cadaver was used. Prior consent had been given. Burns were created by flame and scalding. Unburned control sites also had Nexobrid® applied and were assessed. Nexobrid® enzymatic burn debridement paste was applied to all sites in adherence to the local clinical protocol for treating burned patients. After the removal of Nexobrid®, wounds were assessed to determine if the cadaveric issue appeared similar to what would be expected in living burned patients and whether the technique could be viable for the training of burn care staff.
_Results_
Nexobrid® had a very similar effect upon burned cadaveric skin to what would have been expected in living burned skin. Both scalded and flame-burned sites of partial-thickness burn depth and full-thickness burn depth were debrided and could be clearly identified. Control sites exhibited no skin loss after Nexobrid® application.
_Conclusions_
Fresh-frozen human cadaveric tissue is a valid means of training in the enzymatic burn debridement technique. This permits advanced planning of hands-on training courses in the technique. Timetabled cadaveric courses may allow training of greater numbers of students than the more direct but sporadic clinical experience in acute burns units.
In addition, the degree to which the tissues of the cadaveric model mimicked those of living patients and reacted with the Nexobrid® paste was unexpected. This demonstrates that our understanding of the mechanism of action of Nexobrid® at a molecular level is incomplete.

P.026 Human Cadaver Model as a Training Tool for Enzymatic Burn Debridement (Nexobrid®): A Feasibility Study

Dear friends and colleagues,

We will be pleased to welcome you in Turin (Italy) for the 19th European Burns Association´s Congress in 2022. Italy is honored to hold the meeting of the European Burns Association for the second time, after Verona in 1995. Turin is easily reachable from everywhere in Europe, either travelling by car, train or choosing flight connections. During the meeting, held in the renewed industrial center of the main Italian historical automotive factory (i.e. Lingotto-FIAT), we will meet international burn specialists, focusing on standards of care, progresses in burn treatment, strategies to face disaster situations, with a special attention to education of younger colleagues. However, in your spare time, you might enjoy the sweet days of Italian late summer, simply wandering in the green parks and gardens along the two rivers which cross the city, or you might decide to discover the numerous art galleries, churches, palaces, libraries, walking across elegant squares and large boulevards, passing through centuries of art and history; finally, you may choose to immerse yourself in some of the most exciting museum experiences, such as the Cinema Museum and the Turin’s Egyptian museum.

Looking forward to seeing you all in Turin for the 19th European Association´s Congress in 2022!
Maurizio Stella, Congress President, Turin Burn Centre