Identification of independent risk factors for the treatment of third degree burns with the NovoSorb biodegradable temporizing matrix (BTM) in a multifactorial logistic regression analysis.
Authors
Felix H. Vollbach, Benjamin F. Thomas, Laura C. Siegwart, B. Bliesener, U.Kneser
Objectives
NovoSorb biodegradable temporizing matrix (BTM) got the European approval in November 2019. Since then it has been successfully used in the treatment of multiple complex wounds including surgical, traumatic and infectious full thickness defects besides third degree thermal wounds. Independent risk factors affecting the ingrowth of the BTM and subsequently the take of the skin graft, have not been analyzed yet. Here we report on our 2 years experience in the treatment of 88 burn patients using a multifactorial logistic regression analysis.
Methods
Since the introduction in our clinic in march 2020, all burn patients treated with BTM (n=88) were included in the analysis. Only third degree burns were treated with BTM. Demographic, traumatic, reconstructive, as well as surgical data were compiled, and multifactorial binary logistic regression models were computed to identify independent predictors for its ingrowth and skin graft take.
Results
Out of 88 patients with third degree burns (38 female, 50 male) 5 Patients died (5.7%, 2 female, 3 male). The mean age and BMI were 55.7 years (± 20.1 years) and 27.3 kg/m2
(± 5.7). The mean percentage of total body surface area burnt (% TBSA) was 18% (± 19.4, min 0.2%, max 95%) and an average of 4.8% TBSA (± 7.9, min 0.2%, max 49%) was treated with BTM. The mean period between the trauma and BTM application and subsequent skin transplantation was 13 days (± 14.4 days) and 30 days (± 6.6 days). The mean BTM and skin graft take was 84.8% (± 22.7%) and 86.3% (± 23%). Upon multifactorial binary regression analysis, BTM take (p=0.001), BTM infection (p=0.001), prior cadaver skin allograft (p=0.02), exposure of bone (p=0.01), diabetes mellitus (DM) (p=0.04) and peripheral artery disease (PAD) (p=0.01) proved to be independent risk factors for impaired BTM and skin graft take.
Conclusion
Good BTM take is the most important factor influencing skin graft take. Therefore early debridement and instant BTM application should be emphasized to avoid infection. In cases with impaired vasculature of the wound bed systemic or topic antibacterial treatment should be applied.

**Identification of independent risk factors for the treatment of third degree burns with the NovoSorb biodegradable temporizing matrix (BTM) in a multifactorial logistic regression analysis.**
**Authors**
Felix H. Vollbach, Benjamin F. Thomas, Laura C. Siegwart, B. Bliesener, U.Kneser
**Objectives**
NovoSorb biodegradable temporizing matrix (BTM) got the European approval in November 2019. Since then it has been successfully used in the treatment of multiple complex wounds including surgical, traumatic and infectious full thickness defects besides third degree thermal wounds. Independent risk factors affecting the ingrowth of the BTM and subsequently the take of the skin graft, have not been analyzed yet. Here we report on our 2 years experience in the treatment of 88 burn patients using a multifactorial logistic regression analysis.
**Methods**
Since the introduction in our clinic in march 2020, all burn patients treated with BTM (n=88) were included in the analysis. Only third degree burns were treated with BTM. Demographic, traumatic, reconstructive, as well as surgical data were compiled, and multifactorial binary logistic regression models were computed to identify independent predictors for its ingrowth and skin graft take.
**Results**
Out of 88 patients with third degree burns (38 female, 50 male) 5 Patients died (5.7%, 2 female, 3 male). The mean age and BMI were 55.7 years (± 20.1 years) and 27.3 kg/m2
(± 5.7). The mean percentage of total body surface area burnt (% TBSA) was 18% (± 19.4, min 0.2%, max 95%) and an average of 4.8% TBSA (± 7.9, min 0.2%, max 49%) was treated with BTM. The mean period between the trauma and BTM application and subsequent skin transplantation was 13 days (± 14.4 days) and 30 days (± 6.6 days). The mean BTM and skin graft take was 84.8% (± 22.7%) and 86.3% (± 23%). Upon multifactorial binary regression analysis, BTM take (p=0.001), BTM infection (p=0.001), prior cadaver skin allograft (p=0.02), exposure of bone (p=0.01), diabetes mellitus (DM) (p=0.04) and peripheral artery disease (PAD) (p=0.01) proved to be independent risk factors for impaired BTM and skin graft take.
**Conclusion**
Good BTM take is the most important factor influencing skin graft take. Therefore early debridement and instant BTM application should be emphasized to avoid infection. In cases with impaired vasculature of the wound bed systemic or topic antibacterial treatment should be applied.

P.110 Identification of independent risk factors for the treatment of third degree burns with the NovoSorb biodegradable temporizing matrix (BTM) in a multifactorial logistic regression analysis.

Dear friends and colleagues,

We will be pleased to welcome you in Turin (Italy) for the 19th European Burns Association´s Congress in 2022. Italy is honored to hold the meeting of the European Burns Association for the second time, after Verona in 1995. Turin is easily reachable from everywhere in Europe, either travelling by car, train or choosing flight connections. During the meeting, held in the renewed industrial center of the main Italian historical automotive factory (i.e. Lingotto-FIAT), we will meet international burn specialists, focusing on standards of care, progresses in burn treatment, strategies to face disaster situations, with a special attention to education of younger colleagues. However, in your spare time, you might enjoy the sweet days of Italian late summer, simply wandering in the green parks and gardens along the two rivers which cross the city, or you might decide to discover the numerous art galleries, churches, palaces, libraries, walking across elegant squares and large boulevards, passing through centuries of art and history; finally, you may choose to immerse yourself in some of the most exciting museum experiences, such as the Cinema Museum and the Turin’s Egyptian museum.

Looking forward to seeing you all in Turin for the 19th European Association´s Congress in 2022!
Maurizio Stella, Congress President, Turin Burn Centre