Generic health-related quality of life (HRQoL) instruments, such as EQ-5D, are important tools in economic evaluations for measuring disease burden and generating quality-adjusted life years (QALYs). Our goal was to compare measurement properties of two versions of this instrument, the EQ-5D-3L (3L) and the EQ-5D-5L (5L) in atopic dermatitis (AD). We conducted a multicentre cross-sectional survey in Hungary, involving 218 adult AD patients with mild to severe disease. The 3L and 5L demonstrated good agreement with an intraclass correlation coefficient of 0.815 (95%CI 0.758-0.859, p<0.001). The ceiling effect was reduced by 4.6-11.5% for the mobility, self-care, usual activities, and pain/discomfort dimensions of 5L compared to the 3L. In the 5L, 84 unique health state profiles occurred, while only 33 in the 3L. Average relative informativity was higher for the 5L version (Shannon’s evenness index: 0.64 vs. 0.59) and it demonstrated better convergent validity with EQ VAS, DLQI, and Skindex-16. Both versions were similarly able to distinguish among groups of patients based on disease severity and skin-specific HRQoL with moderate or large effect size (η2=0.083-0.489). To sum up, the 5L version performed better than the 3L in terms of ceiling effect, informativity, and convergent validity, thus we recommend the use of 5L for measuring health outcomes and calculating QALYs in AD.

ESDR082 - Comparing psychometric properties of EQ-5D-3L and EQ-5D-5L in atopic dermatitis

The scientific meeting of the European Society for Dermatological Research (ESDR) is held yearly, usually in September. With an international attendance of more than 1000 skin scientists from around the globe, the four-day event includes short oral presentations from peer-reviewed abstracts, keynote lectures from international experts, sponsored symposia, satellite programs, educational events as well as an important focus on posters, networking and building collaborations amongst scientists. For more information about this year’s meeting visit our website.