Self-assembled peptide–metal frameworks comprised of ≤ 3 residues have shown great promise as proteomimetic materials capable of performing complex functions. Their development has been limited by a lack of mutability and availability of side-chains which can coordinate with metal ions. Here we report a novel, porous, protein-like material that leverages π-stacking interactions to self-assemble into a crystalline framework resistant to several mutations. Exploiting the facile nature of amino acid residues, we evolved this material to exhibit diverse functionalities such as induced-fit host-guest chemistry, metal coordination, and increased affinity for a specific organic substrate. Overcoming the challenges faced by previously reported peptide-based scaffolds, this material shows immense potential in the fields of chiral separation, adaptive substrate binding, catalysis and metal chelation.

Ref: Pandya, A.; Heinz-Kunert, S. L., et al. J. Am. Chem. Soc. 2022, 144(15), 7001-7009.

Self-assembled peptide–metal frameworks comprised of ≤ 3 residues have shown great promise as proteomimetic materials capable of performing complex functions. Their development has been limited by a lack of mutability and availability of side-chains which can coordinate with metal ions. Here we report a novel, porous, protein-like material that leverages π-stacking interactions to self-assemble into a crystalline framework resistant to several mutations. Exploiting the facile nature of amino acid residues, we evolved this material to exhibit diverse functionalities such as induced-fit host-guest chemistry, metal coordination, and increased affinity for a specific organic substrate. Overcoming the challenges faced by previously reported peptide-based scaffolds, this material shows immense potential in the fields of chiral separation, adaptive substrate binding, catalysis and metal chelation.

**Ref:** Pandya, A.; Heinz-Kunert, S. L., et al. _J. Am. Chem. Soc._ 2022, 144(15), 7001-7009.

Self-assembly of peptides into a porous and dynamic protein-like lattice by π-stacking

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