Increasing life expectancy and the risk of joint and bone diseases are major challenges of the global community. To address these challenges, the need for bone replacements has been considered as an alternative. Bone scaffolds should mimic the natural structure of the bone matrix, with similar mechanical and structural (porous) characteristics. Also, the scaffolds should have the affinity to bind to living tissues, and they should be degradable in a certain period. In this study, an attempt was made to use natural material to create a scaffold with similar strength properties to those of bones. In this work, nanocrystalline cellulose (CNC) was prepared from microcrystalline cellulose powder (MCC) via acid hydrolysis. Iron oxide nanoparticles were also prepared by the co-precipitation method. Then, the nanoparticles were synthesized by electrospinning and sensitized with a coating polymer that could crosslink with collagen protein polymers. The last step of the material production was to make hydroxyapatite nano-powder by sol-gel method. Afterward, the mechanical, chemical and structural properties of the produced nanocomposites were comprehensively evaluated. Furthermore, the culture of mesenchymal cells was used along with the prepared material for evaluating the adhesion and interaction of mesenchymal cells to the generated material. The results indicated that the constructed composite 1) was a porous material, and 2) had suitable compression and resistant properties for bone replacement. The above technique can be considered for inducing scaffolds for damaged sites, such as joints.

Preparation of a cellulose nano crystal based composite for bone regeneration

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.