We are developing DNA-scaffolded synthetic catalysts, featuring multiple abiotic functional groups organized in supramolecular active sites, and applying these catalysts in synthetic methodology and chemical biology. We have shown that synergistic catalytic reactions, such as Cu-TEMPO-catalyzed aerobic alcohol oxidation, can be accelerated 100-fold by holding the co-catalysts in proximity on a DNA scaffold. By fine-tuning the sites of co-catalyst attachment on diverse DNA nanostructures, we are developing new stereo- and regio-selective transformations. Taking advantage of combinatorial self-assembly and DNA barcoding, we have developed a high-throughput platform for synthesizing large libraries of supramolecular catalysts (thousands to millions) in a single test tube, then rapidly identifying which catalysts are most active. We have also developed switchable DNA catalysts, which activate or deactivate in response to specific chemical triggers. These switchable DNA catalysts can be activated site-specifically on the surface of living cells, enabling the detection of protein-protein interactions and the mapping of subcellular proteomes.

Enzyme-mimicking DNA-scaffolded synthetic catalysts

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.