Perfluoroalkyl acids (PFAAs), including perfluoroalkyl carboxylates (PFCAs) and perfluoroalkyl sulfonates (PFSAs), are fluorinated fatty acid-like chemicals. PFAAs with longer chain lengths (&gt; C8) preferentially accumulate in the liver. The clearance of PFAAs is species- and chain-length dependent. In rats, there is also a marked gender difference for specific compounds. Serum elimination half-lives can range from a few hours in female rats to several years in humans. Based on results obtained with in vitro expression systems, the gender differences in the excretion of PFCAs in rats (female &gt; male) can be explained by the male-specific expression of an organic anion transporting polypeptide (OATP1A1) important for the reabsorption of these compounds in the kidneys. Liver accumulation of longer chain length compounds can be explained by their transport via transporters involved in the enterohepatic circulation of bile acids, such as the Na<sup>+</sup>/taurocholate cotransporting polypeptide (NTCP), OATP1B1, OATP1B3, and OATP2B1. Thus, the disposition of PFAAs can be explained by the expression of specific transporters in different organs.

Can Drug Transporters explain the Disposition of Perfluorinated Compounds?

Fall 2022 abstracts, posters, and presentations will launch in mid-September.

ACS Fall 2022

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.