Copper(II) complexes have been synthesized by the reaction of Cu(ClPhen)Cl<sub>2</sub> (where ClPhen = 5-chloro-1,10-phenanthroline) with silver triflate in acetonitrile, followed by the addition of an antimetabolite including acetamide, isonicotinamide, 4-pyridinecarbonitrile, imidazole, and theophylline. The new complexes show the Cu(II) metal center in a distorted square pyramidal geometry with one ClPhen and two antimetabolite molecules in the inner coordination sphere. The new complexes have been characterized by infrared spectroscopy, elemental analysis, and X-ray diffraction, and their antitumor activity was determined against MCF-7 breast cancer cells.

Synthesis, characterization, and antitumor activity of copper(II) complexes with 5-chloro-1,10-phenanthroline

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