Ticks are vectors for various diseases such as Lyme disease and Rocky Mountain Spotted Fever. Popular methods to prevent the spread of tickborne diseases have led to problems such as pesticide resistance and environmental contamination by harmful chemicals. Various gene knockdown methods have shown success; however, most methods of dsRNA delivery are invasive and not feasible for large scale application. Glycohydrogels are biocompatible networks that can be designed for drug delivery, however, there is a lack of understanding regarding the effects of glycomonomer stereochemistry and amphipathic comonomer ratio on the network stability, adhesive, and diffusive properties. For this research, glycopolymer-based hydrogels were synthesized via thermal free radical polymerization with varying copolymer compositions and were characterized using rheology to investigate the hydrogel network stability. Thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC) were also completed to understand the structural water properties and swelling behavior.

Structure-property relationships of bioinspired glycohydrogels for transcuticular drug delivery applications

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ACS Spring 2023

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