Promazine drugs are pharmaceuticals known for the management of psychotic disorders such as schizophrenia. One of the major drawbacks of these drugs is their conversion into various amorphous and crystalline structures (aka polymorphism) with different or no biological activity which impacts their efficacy. To address this issue, we previously showed that promazine, chlorpromazine, and triflupromazine drugs can be converted into a liquid state by combining these cations with multiple anions in various molar ratios. The resulting compounds are known as double salt ionic liquids (DSILs) and are multiplex liquid state compounds that retain the pharmacological properties of the constituent ions in addition to improving the aqueous solubility and bioavailability of these compounds. The work presented here focuses on using 1H-15N HMBC Spectroscopy to characterize new promazine DSILs obtained by combining promazine cations with ibuprofenate and docusate anions in three different molar ratios (1:0.1:0.9; 1:0.5:0.5; and 1:0.9:0.1).

1H-15N HMBC characterization of promazine DSILs

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