Heparin is a potent, pharmaceutical anticoagulant agent commonly isolated from porcine intestinal mucosa. While different resins, such as Amberlite FPA98 Cl-, currently exist for the uptake of heparin, these are often difficult to manufacture, expensive, and environmentally unsafe. To this end, the use of Zeolite imidazole framework-8 (ZIF-8), a metal organic framework (MOF), as a heparin adsorbent resin was explored due to its increased surface area, porosity, and stability at high temperatures. The results of this research demonstrated that ZIF-8 had the capacity to recover more than 90% of heparin from 1000 PPM pure heparin aqueous solution. The effects of different experimental variables on heparin uptake into the ZIF-8 resin have been extensively explored.

Efficient heparin recovery using metal organic frameworks

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