Magnetic Resonance Imaging (MRI) is a type of diagnostic imaging often used for scanning soft tissue within the body that often requires the use of contrast agents to enhance the quality of the digital image produced. These contrast agents are typically based on the element gadolinium, which is a known nephro- and neurotoxin to the human body. Because of the potential dangers of gadolinium-based contrast agents, it would be advantageous to develop a novel, safer, alternative. Iron based analogs are attractive due to their reduced toxicity and natural abundance in the body.<br/><br/>Octahedral iron (II) complexes may be ideal candidates to replace gadolinium-based contrast agents, specifically for MRI used in conjunction with thermal tumor ablation therapies, because of the spin crossover that is observed for many of these types of compounds. For tumor ablation therapies, finding an appropriate temperature range in which a spin crossover would occur is critical for future applications. To find suitable candidates for this application, several new tridentate ligands and their iron (II) complexes have been made. The magnetic susceptibility at various temperatures for these new complexes have been measured and their results will be presented.

Ligand effects on the temperature dependent spin crossover of iron(II) complexes

Where thousands of chemistry professionals meet to share ideas and advance scientific and technical knowledge. Spring 2023 abstracts, posters, and presentations will launch at the end of March.

ACS Spring 2023

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.