One of the most common and valuable pharmaceutical reactions is the formation of amides, which most often requires the use of toxic and hazardous reagents. Since 2019, the Boisvert lab has been working on utilizing cheap boric acid (B(OH)<sub>3</sub>) as a catalyst for clean, direct amidation reactions. On its own, boric acid is not a very active amidation catalyst. The goal of this research is to find additives that will increase boric acid's catalytic activity. Various additives were screened, and the results were analyzed using <sup>1</sup>H NMR spectroscopy. Reactions were replicated on the gram scale to study the scope of the new promising catalytic system and expand the usefulness of boric acid in catalytic amidation reactions.

Direct amidation using boric acid and additives

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