Topoisomerase inhibitors play an important role in the fight against cancer. The focus of this research is to create a suite of pharmaceutically relevant terpene derivatives based on the trachylobane family of diterpenes. These candidate molecules can then be evaluated for topoisomerase inhibition. Past work has expanded the diterpene core to include thiosemicarbazone functionalities. This work aims to expand the ring system in the commercially available diterpene carvone towards that of the trachylobane of interest. The scope of this synthesis and the novel molecules produced were evaluated for reproducibility and usefulness in the inhibition of topoisomerase.

Synthesis of pharmaceutically relevant terpene derivatives for use as topoisomerase inhibitors

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