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Oct 29, 2018

7th Congress of the European Academy of Paediatric Societies

0476 - THE EFFECT OF COMBINED THERAPY FOR TREATMENT OF MONOTHERAPY RESISTANT PDA IN PRETERM INFANTS

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paracetamol

ibuprofen

combined treatment

Abstract

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21

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Abstract

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Keywords

paracetamol

ibuprofen

combined treatment

Abstract

Objective: Hemodynamically significant PDA (hsPDA) is one of the most common problems in preterm infants. This study was conducted to investigate the effect of combined pharmacological (paracetamol+ibuprofen) therapy on monotherapy-resistant hsPDA in infants. Subject and methods: The study included infants with persistent hsPDA, unresponsive to monotherapy. Combined treatment (paracetamol+ibuprofen) was started as paracetamol at a dose of 15 mg/kg every 6 hours for 5 days, and ibuprofen at an initial dose of 10 mg/kg followed by 5 mg/kg at 24 and 48 hours. Echocardiographic evaluation was performed at 2 days after the end of treatment. If hsPDA persisted after the combined treatment, a surgical PDA ligation was considered. Results: A total of 12 infants were enrolled and 9 infants (75%) with monotherapy-resistant PDA were successfully treated with combined therapy. In 3 patients, no response was obtained to the combined treatment so surgical ligation was applied. Conclusion: Combined therapy may be a useful treatment option for monotherapy-resistant hsPDA in preterm infants. Before surgical ligations, this combined therapy option should be considered.

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© Copyright 2019 Morressier GmbH.
All rights reserved.