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Oct 14, 2018

7th Congress of the European Academy of Paediatric Societies

06 - BRAIN GROWTH IN EXTREMELY PRETERM CHILDREN REPEATEDLY SCANNED WITH MRI AT TERM AGE AND LATE CHILDHOOD.

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preterm children

neonatology

mri

Abstract

Abstract

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Keywords

preterm children

neonatology

mri

Abstract

Title: Brain growth in extremely preterm children repeatedly scanned with MRI at term age and late childhood. Background: There are few longitudinal studies investigating how brain volume of preterm children changes over time and to the best of our knowledge no studies of extremely preterm children (EPT). In this study we repeatedly examined a unique population of EPT children from term age to late childhood. This adds important knowledge since more and more EPT born survive. It is of further importance to detect structure-function relationships to identify possible biomarkers that would help us find children with risk of developmental problems at an early stage. Method: The cohort consisted of live-born children born before week 27 in Stockholm area between 2004-2007. We included 48 high quality MRI scans at term age and 58 scans at age 9-11. Out of these 28 subjects had high quality scans at both time point. A control group of 15 healthy children born full term scanned at term age and a group of 38 full term born children scanned at late childhood were included. Volume calculations were done for white and grey matter after brain extraction and automatic segmentation. Children with periventricular leukomalacia (PVL), moderate-severe white matter abnormalities, intraventricular hemorrhage grade 3-4 and focal brain lesions were excluded. We subtracted the absolute tissue volume at late childhood with the mean absolute tissue volume at term to calculate the absolute tissue growth from term age to late childhood. For the 28 children with longitudinal data we subtracted the volume at late childhood with the volume at term age for each individual child. We considered growth of cerebral parenchyma (CPAR) as covariate. Sex and age at scan did not have any effect on results. A general linear model was used for statistical analysis in SPSS, p<0,05 was considered significant. Results: The grey matter growth from term age to late childhood was 571,95 cm3 in the EPT group and 595.18 cm3 in the control group. The white matter growth was 279,71 cm3 in the preterm group and 322,67 cm3 in the control group. For the 28 children that had usable MRI at both time points there was 566,19 cm3 grey matter growth and 293,06 cm3 white matter growth in the EPT group. For children born extremely preterm there was a significantly less brain growth for both grey and white matter both in the whole cohort and in the children with high quality MRI at both time points. Age at scan or sex did not differ between groups. When corrected for growth CPAR the white and grey matter growth restriction persisted. Conclusion: Brain growth is impaired in extremely preterm (EPT) children during childhood. We found significantly slower brain volume growth for both grey and white matter in extremely in EPT children compared with full-term controls.

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© Copyright 2019 Morressier GmbH.
All rights reserved.