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Jun 29, 2018

MASCC/ISOO Annual Meeting on Supportive Care in Cancer

07 / COGNITIVE BEHAVIORAL EFFECTS ON TOTAL WAKE TIME IN WOMEN WITH GYNECOLOGIC MALIGNANCIES AND INSOMNIA

;

Padron;

A.;

Cartagena;

G.;

McCrae;

C.S.;

Robinson;

M.E.;

Trinastic;

L.;

Postupack;

R.A.;

Esperza-Duran;

D.;

Kacel;

E.;

Schultz;

G.;

Castagno;

J.

psycho-oncology

total wake time

cognitive behavioral therapy

gynecologic cancer

sleep

Abstract

Abstract

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Keywords

psycho-oncology

total wake time

cognitive behavioral therapy

gynecologic cancer

sleep

Abstract

Introduction: Sleep disturbance is a common outcome associated with cancer diagnosis and treatment that contributes to depression, low quality of life, and morbidity. While there is evidence for the effectiveness of Cognitive Behavioral Therapy for insomnia (CBTi) in breast cancer survivors, there exists a lack of empirical evidence on its efficacy within gynecologic malignancies. Objectives: To examine the effects of a CBT intervention for insomnia and pain (CBTip) subjective Total Wake Time (TWT) in women with confirmed gynecologic cancers. Methods: Participants were 35 women with insomnia status/post surgery for gynecologic cancer randomized to either a 6-week individual CBTip intervention (N=18) or a 6-week individual Psychoeducation program (N=17). Subjective TWT was assessed via 14 days of sleep diaries at baseline (Wk0), post-intervention (Wk7), 2-month follow-up (Wk14), and one-year follow-up (Wk66). Mixed linear modeling (MLM) was conducted to examine longitudinal group differences on subjective TWT with planned contrasts examining group differences in TWT at Wk7, Wk14, and Wk66. Results: Immediately post-intervention at Wk 7, CBTip participants showed a nonsignificant trend toward lower TWT (b=-28.15, p=0.055) compared to Psychoeducation participants. By Wk14, this trend was fully significant, such that CBTip participants demonstrated significantly lower TWT (b=-32.24, p=0.036) compared to Psychoeducation participants. However, there were no group differences in TWT at Wk66. Conclusions: CBTip significantly reduced subjective TWT in women with gynecologic cancers and insomnia during the acute post-surgical treatment phase. Future research will focus on bidirectional effects of sleep and Hypothalamic-pituitary-adrenal (HPA) axis dysregulation.

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© Copyright 2019 Morressier GmbH.
All rights reserved.