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Sep 23, 2018

7th Congress of the European Academy of Paediatric Societies

07 - MANAGEMENT OF INFANTS BORN TO HEPATITIS B SURFACE ANTIGEN POSITIVE MOTHERS - A RETROSPECTIVE REVIEW

hepatitis b

vaccination

vertical transmission

immunisation

Abstract

Abstract

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Keywords

hepatitis b

vaccination

vertical transmission

immunisation

Abstract

Background and Aims: Transmission of Hepatitis B virus (HBV) during delivery is the most frequent method of vertical transmission. Although immunoprophylaxis within 24 hours of birth is 95% efficacious in preventing perinatal transmission, it remains the most common route of hepatitis B spread in endemic areas1. A retrospective service evaluation was carried out to evaluate the management of infants at risk of perinatal transmission of HBV. Methodology: From Jan 2004 to Jan 2018, records were reviewed of all infants tested for HBV and/or those with maternal hepatitis alert in either antenatal or perinatal notes. A total of 32 cases met the above criteria. Results: Most of the cases were born at full term to mothers with low degree of hepatitis B infectivity. Full compliance was observed with giving the first dose of hepatitis B vaccine within 24 hours of birth (32 cases; 100%), administering hepatitis B immunoglobulins when indicated (5 cases; 100%) and effective communication regarding hepatitis B vaccination schedule to the GP (32 cases; 100%). 75% of the patients received the course of Hep B vaccination as per protocol and had their hepatitis B status assessed at ~15 months of age (69% of those being immune). The remainder of the patients were re-vaccinated. None of them acquired HBV perinatally. Conclusion: Perinatal transmission of HBV is preventable largely through accelerated hepatitis B vaccination. Collaborative efforts and effective communication between the obstetrician, paediatrician and general practitioner is the key to ensure appropriate management and risk reduction in vertical transmission of hepatitis B virus. References: 1. http://www.who.int/mediacentre/factsheets/fs204/en/

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© Copyright 2019 Morressier GmbH.
All rights reserved.