We use cookies to ensure that we give you the best experience on our website Learn more

May 17, 2018

Euroanaesthesia 2018

08 / The efficacy and safety of epidural oxycodone in pain management after gynaecologic laparoscopy

;

model

acute pain service

analgesics opioid

analgesic techniques

extradural

Abstract

Abstract

thumbnail

Keywords

model

acute pain service

analgesics opioid

analgesic techniques

extradural

Abstract

Background: Early pain after laparoscopic surgery is often moderate to severe (1). Epidural oxycodone penetrates readily into cerebrospinal fluid and may be more potent than intravenous (i.v.) oxycodone (2). In this randomised, double blind clinical trial, we have assessed the analgesic efficacy of epidural oxycodone after gynaecologic laparoscopy. Methods: We enrolled 60 women, aged 23-71 years, undergoing elective gynaecologic laparoscopy under standardized general anaesthesia. Postoperatively, the patients were administrated either i.v. saline and epidural oxycodone 0.1 mg•kg-1 (EPI-group, n=31) or i.v. oxycodone 0.1 mg•kg-1 and epidural saline (IV-group, n=29). For background analgesia the subjects received i.v. paracetamol and dexketoprofen. The primary outcome was the amount of i.v. fentanyl for rescue analgesia during the first four postoperative hours. Analysis of data was performed with independent samples t-test. Data is presented as number of cases or median (minimum – maximum). Results: The median amount of fentanyl for rescue analgesia during the first four postoperative hours was 50 (0-450) µg in the EPI-group and 100 (0-550) µg in the IV-group, p=0.025. More patients had pruritus in the EPI-group than in the IV-group, 17 vs. 8, respectively, p=0.032. Conclusion: Analgesic efficacy of epidural oxycodone was superior compared to that of i.v. administration in early pain management after laparoscopic surgery.

Discover over 20,000 new abstracts, posters and presentations from leading academic conferences every month. Stay on top of the latest findings, methodologies and discussions happening in your research field around the world.

Company

Legal

Follow us

© Copyright 2019 Morressier GmbH. All rights reserved.

© Copyright 2019 Morressier GmbH.
All rights reserved.