We use cookies to ensure that we give you the best experience on our website Learn more

Home

Saved research

Aug 22, 2019

EFIC Congress 2019 - Pain in Europe XI

10 - INVESTIGATING THE INTERPLAY BETWEEN ERROR-PROCESSING AND CENTRAL SENSITIZATION

;

Central sensitization

Error related negativity

Error related positivity

EEG

Abstract

25

Views

25

Views

Abstract

Fullscreen

thumbnail

Keywords

Central sensitization

Error related negativity

Error related positivity

EEG

Abstract

Sensitivity to threats plays a pivotal role in the survival of species. Both pain and errors are thought to reflect threats and promote defensive responses. A higher sensitivity to errors has been related to a higher sensitivity to threats, which in turn may promote the development of chronic bodily sensations, such as chronic pain. In this study we have used a human surrogate model of persistent pain (Low Frequency Stimulation of the skin, LFS), and investigated a possible bidirectional relationship between the sensitivity to errors and mechanical hypersensivity developed after LFS. Neural EEG indexes of error processing, i.e. the error related negativity (ERN) and positivity (Pe) were recorded in 40 participants assigned randomly to a control or an experimental group. Both groups performed a Flanker Task at 3 time points (T0, T1, T2), but only the experimental group underwent, between T0 and T1, T2 LFS. We observed that after sensitization, confirmed by the increased perception of mechanical stimuli applied on the sensitized arm (mechanical hypersensitivity), the Pe was reduced in the experimental group. The baseline amplitude of the Pe at T0 partially predicted the amount of hypersensitivity developed at T1. Our results provide a first evidence of a bidirectional influence between errors and pain persistency, where neural indexes of sensitivity to errors may predict the development of hypersensitivity and intense pain modulates neural measures of error-processing.

Company

Legal

Follow us

© Copyright 2019 Morressier GmbH. All rights reserved.

© Copyright 2019 Morressier GmbH.
All rights reserved.