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Jun 19, 2019

MASCC/ISOO Annual Meeting on Supportive Care in Cancer

12 - REDUCTION IN QUALITY OF SKELETAL MUSCLE MAY HAVE AN UNFAVORABLE IMPACT ON FUNCTIONAL PROGNOSIS IN PATIENTS WITH METASTATIC SPINE TUMORS RECEIVING NON-SURGICAL TREATMENT

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metastatic spine tumors

functional prognosis

skeletal muscle index

attenuation of muscle

Abstract

Abstract

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Keywords

metastatic spine tumors

functional prognosis

skeletal muscle index

attenuation of muscle

Abstract

[Introduction] Patients with metastatic spine tumors may have an increased risk for losing skeletal muscle and decreasing physical function due to bed rest and restrictions in movements. The purpose was to clarify the relationship between changes in skeletal muscle quality and functional prognosis in those patients. [Methods] In this historical cohort study, the medical records of inpatients with metastatic spine tumors who received radiotherapy and physiotherapy at Shizuoka Cancer Center were retrospectively collected. Skeletal muscle quantity and quality were evaluated at the time of diagnosis of metastatic spine tumors (Baseline) and one month after starting radiotherapy (T1). Muscle quantity was evaluated with skeletal muscles index (SMI) and quality was evaluated with the proportion of low attenuation muscle area (<29 Hounsfield unit) in the whole muscle area (LAM) on L3 CT slice. The amount of changes in SMI and LAM between baseline and T1 were expressed as ΔSMI and ΔLAM. Single logistic regression analysis was used to assess the effect of ΔSMI and ΔLAM on functional prognosis, or the ability to walk at T1.[Results] A total of 29 patients were analyzed. Five of them (17.2%) were judged as having unfavorable functional prognosis. Variables significantly related to functional prognosis were ΔLAM of the whole lumbar muscle (odds ratio 23.8, 95%CI 1.2-454.7), ΔLAM of psoas major muscle (odds ratio 5.2, 95%CI 1.4-19.2), and ΔLAM of paraspinal muscle (odds ratio 5.0, 95%CI 1.2-19.7). [Conclusion] It was revealed that patients with reduced quality of skeletal muscle during treatment had poorer functional prognosis one month after starting radiotherapy.

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© Copyright 2019 Morressier GmbH.
All rights reserved.