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Jun 19, 2019

MASCC/ISOO Annual Meeting on Supportive Care in Cancer

13 - SCREENING AND TREATMENT OF CARDIOVASCULAR COMORBIDITIES AMONG PATIENTS WITH PROSTATE CANCER WHO START ANDROGEN DEPRIVATION THERAPY

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prostate cancer

androgen deprivation therapy

hormone therapy

cardiovascular

comorbidities

Abstract

Abstract

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Keywords

prostate cancer

androgen deprivation therapy

hormone therapy

cardiovascular

comorbidities

Abstract

INTRODUCTION: Androgen deprivation therapy (ADT) is associated with an increase in cardiovascular (CV) events among patients with prostate cancer (PC). CV comorbidities and risk factors screening is mandated according to international and local guidelines. Mexico has one of the highest rates of metabolic syndrome, and we lack local studies that evaluate compliance with these guidelines in our PC population.  METHODS: Retrospective chart review of patients with PC who started ADT in a single institution from January 2013 to January 2018. We evaluated the screening of CV comorbidities and risk factors from the previous 12 months to the first 3 months since ADT initiation. Implemented therapeutic interventions based on abnormal findings in screening were also assessed.  RESULTS: 100 patients were included, baseline characteristics are described in Table 1: 68% had metastatic disease and GnRH analogs as ADT were used in 92%. Screening of CV comorbidities and risk factors is depicted in Figure 1: diabetes mellitus and overweight/obesity had the highest and lowest detection frequency, respectively. Compliance with international guidelines recommendations is shown in Table 2. 6% of patients had major CV adverse events: 1% myocardial infarction, 2% stroke and 3% pulmonary embolism. CONCLUSIONS: Screening of CV comorbidities in this Mexican cohort with PC is suboptimal, although greater than reported by similar studies. Treatment adherence to guidelines recommendations contrasts with data from cardio-oncology clinics. This real-world setting report stresses the necessity to develop interventions to overcome the unmet needs in our PC population, as resources are scarce.

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© Copyright 2019 Morressier GmbH.
All rights reserved.