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15 / AN ORAL BOTANICAL EXTRACT REDUCES FATIGUE IN A RADIATION-INDUCED FATIGUE MOUSE MODEL

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Abstract

Fatigue is a common and highly distressing symptom following cancer treatments including radiation therapy. It is frequently undertreated in clinical practice. The etiology of cancer-related fatigue is poorly understood, but inflammation and mitochondrial dysfunction have been proposed. Currently, there is no US FDA-approved treatment for cancer-related fatigue. We previously observed significant correlations between changes in the expressions of eight mitochondria-related genes (e.g., BCL2) with worsening of radiation therapy-related fatigue. We also observed that Cellium, a safe botanical extract, inhibited inflammation and normalized BCL2 levels in human alopecia models. The goal of this study is to investigate the anti-fatigue effects of an oral botanical extract on a previously developed peripherally irradiated mouse model.

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© Copyright 2019 Morressier GmbH. All rights reserved.

© Copyright 2019 Morressier GmbH.
All rights reserved.