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Jun 27, 2018

MASCC/ISOO Annual Meeting on Supportive Care in Cancer

15 / AN ORAL BOTANICAL EXTRACT REDUCES FATIGUE IN A RADIATION-INDUCED FATIGUE MOUSE MODEL

;

Saligan;

L.N.;

Wolff;

B.;

Bernier;

C.;

Chretienne;

M.;

Harti;

S.;

Pralong;

W.;

Liu;

J.

fatigue

anti-inflammation

botanical

cellium

Abstract

Abstract

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Keywords

fatigue

anti-inflammation

botanical

cellium

Abstract

Fatigue is a common and highly distressing symptom following cancer treatments including radiation therapy. It is frequently undertreated in clinical practice. The etiology of cancer-related fatigue is poorly understood, but inflammation and mitochondrial dysfunction have been proposed. Currently, there is no US FDA-approved treatment for cancer-related fatigue. We previously observed significant correlations between changes in the expressions of eight mitochondria-related genes (e.g., BCL2) with worsening of radiation therapy-related fatigue. We also observed that Cellium, a safe botanical extract, inhibited inflammation and normalized BCL2 levels in human alopecia models. The goal of this study is to investigate the anti-fatigue effects of an oral botanical extract on a previously developed peripherally irradiated mouse model.

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© Copyright 2019 Morressier GmbH.
All rights reserved.