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Sep 11, 2018

ERC congress - Resuscitation 2018

2 - Comparison of hemodynamic effect and survival rate between the newly developed automatic CPR(X-CPR) device and LUCAS in a swine model of cardiac arrest






Abstract Introduction We conducted a study to compare hemodynamic effect between newly developed motor-driven simultaneous sterno-thoracic cardiopulmonary resuscitation device (X-CPR 2) and Lund University cardiac arrest system (LUCAS 2). Materials and methods Twenty-five pigs were divided into two groups (n=13 in X-CPR2 group). After 2 minutes of ventricular fibrillation (VF), all received CPR with 30:2 compression-to-ventilation ratio for 6 minutes. Thereafter continuous chest compression and intermittent ventilation at rate of 10 per minute were followed for 12 minutes. 2 J/kg was delivered at 6 minutes after VF induction and energy was modified to 4 J/kg if cardiac rhythm was VF on defibrillator. Epinephrine 1 mg was injected every 4 minutes from 8 minutes after VF induction. Hemodynamic parameters including mean aortic pressure (MAP), right atrial pressure (RAP), coronary perfusion pressure (CPP), carotid blood flow (CBF) and end-tidal carbon dioxide pressure (ETCO2) were measured at baseline and every 2 minutes after VF induction. Return of spontaneous circulation (ROSC), 2 hour survival, 24 hour survival and cerebral performance category (CPC) at 24 hours were evaluated. Autopsy was performed to evaluate the device-induced mechanical complications including rib fracture, lung contusion, hemothorax, hemopericardium and hemoperitoneum. Results Hemodynamic parameters were not different between groups except RAP (p=0.002). Total epinephrine dose, defibrillation frequency, rate of ROSC, 2-hour survival rate, 24-hour survival rate and good neurologic outcome (CPC≤2) were also not different between groups. There was also no difference in mechanical complications between groups. Conclusions The hemodynamic effect was not different between X-CPR2 and LUCAS. RAP was maintained higher in X-CPR2 group.

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© Copyright 2019 Morressier GmbH.
All rights reserved.