Palladium (Pd)-catalyzed Suzuki–Miyaura coupling reaction of aryl halides and aryl boronic acid derivatives is one of the most useful synthetic methods for constructing biaryl derivatives as fundamental skeletons of various pharmaceuticals and functional materials. Heterogeneous Pd-catalyzed ligand-free Suzuki–Miyaura coupling reactions have attracted attention as environmentally friendly and metal-contamination-free (or low) methods. Aryl chlorides, which are readily available and less expensive organic compounds in comparison to aryl iodides and bromides, are preferred substrates for the Suzuki–Miyaura coupling reaction, although special ingenuity is necessary for activation of the low-reactive carbon-chloride bond. We have prepared the anatase-, rutile- and brookite-type TiO2-supported Pd catalysts and studied the physical properties of these catalysts by the use of X-ray photoelectron spectroscopy (XPS) and transmission electron microscopy (TEM). Furthermore, the effect on the catalyst activities depending on the crystal form of TiO2 to the TiO2-supported Pd-catalyzed Suzuki–Miyaura coupling reaction was investigated. Consequently, the anatase-type TiO2-supported Pd catalyst was found to have an efficient catalyst activity toward the ligand-free Suzuki–Miyaura coupling reaction of aromatic chlorides due to the highly distributed small Pd nanoparticles (1–2 nm) on the anatase-type TiO2.

Development of titanium oxide-supported palladium catalysts and evaluation of the catalyst activities for ligand-free Suzuki–Miyaura coupling using aryl chlorides

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.