The synthesis of enamines is an important operation in synthetic chemistry. Montmorillonite clay- mediated simple and high yielding protocol to synthesis of various enamines with secondary amines and ketones is developed under microwave condition. This protocol is very convenient to accesses the enamines from cyclic amines with various carbonyl compounds in very high yield under mild reaction conditions with very short reaction time.<br/>Different types of clay-mediated reactions are easy to perform because they are not soluble in organic solvents. Most of the clays or solid surfaces are acidic or neutral in nature. Clays have the capability to absorb water and organic compounds inside the cavity in their structures. It is reported that clays are catalyzed a diverse organic reaction including substitution, addition, elimination, hydrogenation, hydrogenolysis, dehydration, aromatization, annulation, Diels-Alder, and isomerization. These methods are efficient in the synthesis of a wide range of diverse molecules of biological and medicinal interests. Montmorillonite K-10 has been proven its versatile catalytic efficiency in organic synthesis.

Microwave-induced montmorillonite-mediated facile synthesis of enamines

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

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