<br/>Ferrier rearrangement has been extensively used for the synthesis of 2,3-unsaturated glycosides. C-glycoside analogous of the O-glycosides is used as intermediates for the synthesis of numerous medicinally active molecules. Our group has developed numerous novel methods for synthesizing glycosides through Ferrier rearrangement. We herein synthesize glycosyl nitrile from glucal <i>via</i> carbon Ferrier rearrangement of glycal and silyl nitrile in the presence of Hafnium (IV) chloride under microwave irradiation method. Hafnium tetrachloride (HTC) is an efficient catalyst for this purpose.

Microwave-assisted hafnium(IV) chloride-promoted self-coupling of D-glycal

Macromolecular Chemistry: The Second Century

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ACS Spring 2020 National Meeting & Expo

The official archive and repository for all ACS Meetings & Expositions abstracts and select posters or presentations.